The systemic effects of cancer-related inflammation can be easily quantified using routinely available blood parameters such as NLR, PLR and mGPS, all of which have been explored as prognostic traits in NSCLC (Forrest et al, 2005; Arrieta et al, 2010; Tomita et al, 2012).
In our series of HNSCC, when expression values for the probes to GAS5 were explored as prognostic markers, a trend similar to the one seen for RNU44 was observed in Kaplan Meier analyses (Table 1 and Figure 5C, one representative probe shown).
This approach could be explored as a prognostic tool for recovery from coma, and for guiding treatment of status epilepticus.
Importantly, samples showing small tumor-normal tissues differences had higher nucleolar size, indicating that not only the rDNA methylation level, but also the extent of rDNA hypermethylation in respect to normal tissue could represent a marker of breast cancer progression and, in principle, could be explored as a potential prognostic marker for this tumor type.
Therefore MCM7 can be explored as a potential therapeutic and prognostic target in lung and other cancers.
Several miRNAs with potential biological and clinical relevance have been identified and are being explored as diagnostic, prognostic and predictive biomarkers [ 3- 6].
The main role of Topo2 α has been explored as a prognostic and predictive biomarker for anthracyclines in the adjuvant setting and the results thus have been far contradictory.
As inflammation progresses, the adhesion molecules that mediate these interactions become shed from cell surfaces and accumulate in the blood as soluble isoforms that are being explored as potential prognostic disease biomarkers.
In addition to clinical and laboratory-based factors used as prognostic criteria, being MSKCC the most known (Motzer et al, 1999), several molecules have been explored as potential biologic indicators in terms of response to SU11248.
Because of its tumour-specific overexpression, EpCAM has been explored as a prognostic/diagnostic marker and anti-cancer target since the 1970s [ 5].
