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These too may be exploited to target new drugs into trypanosomes.
Our data demonstrate how an evolutionarily refined parasite-derived protein can be exploited to target a common, but complex, malignancy-associated glycosaminoglycan modification.
On top of this, LARS programs extend Answer Set Programming (ASP) with rich stream reasoning capabilities; the latter can be exploited to target AI applications in a streaming context, such as diagnosis, configuration or planning.
Expression of active KLKs by cancer cells and tissues can be exploited to target prodrugs that are proteolytically cleaved to release a cytotoxic compound or a cytolytic toxin at the site of KLK protease activity.
If such information were known, it could allow for aminoglycosides to be exploited to target other RNAs and, in addition, could provide invaluable insights into potential bystander targets of these clinically used drugs.
We review a class of liposome-based drug-delivery systems whose design and functional properties are intimately controlled by the stability of sub-micron structures, lipid-bilayer interfaces, and interfacially activated enzymes that can be exploited to target and deliver drugs.
Similar(45)
This is important for the design of antiprotozoal drugs where differences between host and parasite orthologs are exploited to target the parasite selectively and minimize side-effects [55].
Nowadays, several alkaloids are currently being exploited to target angiogenesis.
Many strategies have been exploited to target tumours.
In some cases (CD30, Fn14), the tumor-associated expression pattern of certain TNFRSF receptors is exploited to target tumor cells with ADCC-inducing antibodies or antibody immunotoxins.
The absence of hTRM9L leads to a sensitivity to paromomycin, a finding that can be exploited to specifically target hTRM9Lnegative/low tumour cells.
More suggestions(18)
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