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Thus, IS3 blockade could potentially be exploited to overcome TKI resistance in CML.
Since NF-κB has been implicated in chemoresistance and radioresistance (Jung and Dritschilo, 2001; Bharti and Aggarwal, 2002), NF-κB inhibitory activity of NSAIDs can be exploited to overcome chemoresistance and radioresistance.
Like other protein protein interactions, receptor chemokine complexes are considered challenging therapeutic targets for small molecules, and the present structure suggests diverse pocket epitopes that can be exploited to overcome obstacles in drug design.
I highlight how randomization and simulation routines, generalized linear mixed models, autocorrelation models, phylogenetic comparative methods and Bayesian statistics can be exploited to overcome the inefficient performance of some conventional statistical approaches with typical behavioural data.
Not only temperature but also substrate position and graphene thickness play significant role in determining the properties of the grown ZnO structures by thermal evaporation because these factors can be exploited to overcome the problem of graphene's oxidation that takes place during the growth.
This knowledge may be exploited to overcome some ARDs affecting the nervous system (such as Alzheimer's, Parkinson's or Huntington's disease).
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Conversely, covalent linking of individual protein subunits into single polypeptide chains are exploited to overcome sample preparation bottlenecks.
Several attempts have been exploited to overcome the ICL issue, but all of them involved time consuming and inevitable electrolyte decomposition.
A wide range of advanced drug delivery systems including polymeric controlled release systems, cell-based delivery and nanowafers are being exploited to overcome the challenges of frequent administration to ocular tissues.
Adaptive modulation is exploited to overcome the performance enhancement limitation in source rate control schemes employing fixed modulation.
A signal reconstruction based on Bayesian statistics for noise reduction was exploited to overcome the low signal-to-noise ratio.
More suggestions(16)
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