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An array of plasma treatment approaches (hydrophobic and hydrophilic) can be exploited to manipulate the surface of polymer membranes for a variety of applications.
These results emphasize the importance of previous light history in chronobiology [42] and raise the possibility that appropriate manipulation of spectral light composition in industrial, domestic and in clinical phototherapy applications can be exploited to manipulate the response capacity of melanopsin-dependent circadian and other non-visual responses.
This promoter variant is predicted to affect transcription factor binding and it may therefore highlight a regulatory site that could be exploited to manipulate GDF5 expression and alleviate the detrimental effect mediated by the T-allele of rs143383.
Moreover, detailed further analysis and extension of our mass spectrometric studies in ECs will allow us to fully explore how differential adhesion dynamics, mediated by distinct integrin-ECM interactions, result in the formation of unique signalling platforms that can be exploited to manipulate angiogenic responses.
If the −41 bp variant does highlight a genuine regulatory domain of GDF5, then this may offer us with a DNA site that could be exploited to manipulate the expression of the gene and therefore potentially alleviate the detrimental effect that the T-allele of rs143383 has on GDF5 expression and therefore on OA risk.
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Dielectrophoresis has been exploited to manipulate uncharged nanoscale objects in dielectric liquid medium.
In several recent studies, these effects have successfully been exploited to manipulate protein scaffolds, resulting in improved catalytic activity and altered substrate or ligand binding affinity, as well as enabling the design of novel biocatalysts and biosensors.
Magnonic crystals (MCs) [4 12], as the magnetic counterpart of PhCs, also exhibit the bandgap and dispersion relation properties that can be exploited to control and manipulate spin waves (SWs) and also to produce effects that are not possible with isolated magnetic nanostructures.
The potential invasion of new pests has often been facilitated by their mutualists and some novel interactions have resulted in new and more virulent insect pests., Manipulating symbionts may be exploited to improve pest control and finding out more about insects and their microbial associates will be both fascinating and useful.
Gene targeting by homologous recombination is a powerful method to manipulate the genome precisely and could be exploited to correct genetic defects.
A better understanding of miRNA physiology could be exploited, to elucidate the etiology of the disease, and manipulated to reduce obesity, as has already been done in animal studies for microRNA-122 [ 65].
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