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However, are there targets that can be exploited to eradicate CSCs without affecting healthy stem cells?
Investigation of how the ferret immune response may be exploited to eradicate or prevent H. mustelae infection could be informative for preventing H. pylori infection in humans.
Moreover, it is plausible that anti-inflammatory drugs that simultaneously target both the COX2/PGE2 and NFκB pathways, such as ASA, can be exploited to eradicate CSCs.
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Two main strategies are currently being exploited to eradicate the cancer stem cell (CSC) pool: i) chemotherapeutic regimens that specifically drive CSC into apoptosis and thereby deplete the CSC reservoir of the tumor, and ii) strategies aiming to drive CSC into differentiation and thereby increase their susceptibility to pro-apoptotic treatments [1].
The two main strategies that are currently being exploited to eradicate CSCs are (a) chemotherapeutic regimens that specifically drive CSCs toward cell death and (b) those that promote the differentiation of CSCs, thereby depleting the tumour reservoir.
Thus, the process of metastasis could be exploited as an opportunity for eradicating cancer cells, particularly during their dormant period, which is probably underpinned by resistance to DICD or anchorage-independent cell growth and survival.
The concept of intratumoral cell competition among heterogeneous clones reshaped our classic hierarchical view of heterogeneity and potentially can be exploited as therapeutic entry points in eradicating multifocal cancers [ 77].
There was cheap land to be exploited.
Good buys are waiting to be exploited.
Dr. King died standing up for workers who were being exploited and underpaid because he understood that the only way we get to be One Nation is to eradicate poverty.
But Mr Durham thinks that there's very little that could be done to eradicate malicious squatters and others seeking to exploit the system.
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