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Here, we systematically assess how multiple crystallographic receptor conformations, a powerful way of discretely representing protein plasticity, can be exploited in screening protocols to separate binders from non-binders.
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The in vitro protease assays with recombinant PfHslV and the transgenic parasite line generated in the present study may be exploited in the screening of novel inhibitors to evaluate their anti-malarial activity.
Protein microarrays could be exploited in the screening [ 42].
Therefore, InCell SMART-i may be exploited in systematic screening of diverse molecular interactions inside living cells, as it efficiently eliminates intrinsic false positive/negative modes or error-prone deviations.
It can also be exploited in array-based screening and in-vivo bio-species diagnostics.
Several proteins have emerged as putative candidate biomarkers and, hopefully, the negative correlation between THBS1 and TGFBI expression that we have encountered can be exploited in the next future for screening the presence of OA disease or monitoring therapeutic effectiveness in clinical samples.
Genes that respond transcriptionally to VPA in embryos (Supplemental Material, Tables 1 and 2) may provide not only important clues about mechanisms of VPA action but also potential biomarkers of VPA teratogenicity that could be exploited in a cell-based screening system.
New approaches and technologies should be exploited in future studies.
These findings could be exploited in several ways.
This principle can be exploited in liver bioengineering.
"Chemical suppression" has also been exploited in model organisms to screen a collection of small molecules for their capacity to reverse a specific phenotype due to genetic mutations (Baraban et al. 2013; Cao et al. 2009; Peal et al. 2011; Peterson et al. 2004; Su et al. 2010).
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