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We briefly evaluate the structure and function of these receptor molecules, emphasizing the elegant mechanisms by which certain characteristics of cancer can be exploited in cancer treatment.
This work provides an additional mechanistic explanation for c-Myc-induced DNA damage and senescence, and reveals a vulnerability of c-Myc overexpressing cells that could potentially be exploited in cancer therapy.
Whether targeting autophagy can be exploited in cancer treatment remains controversial.
This may result in maladaptive or suboptimal behaviours that could be exploited in cancer treatment.
Loss of checkpoint mechanisms is frequently found in cancer, a trait which can be exploited in cancer therapy.
The increased dependence of cancer cells on these pathways for survival can be exploited in cancer therapy by either stress sensitization or stress overload.
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These properties of Pt are exploited in cancer therapy in the form of antineoplastic drugs to treat different types of cancer such as head, neck, brain [4], testicular, bladder, ovarian, or uterine cervix carcinomas [5].
On the other hand, despite tremendous resources being exploited in cancer biology and clinical oncology, there are progressively increasing failure rates, high cost, low bioavailability, poor safety, limited efficacy, and a lengthy design and testing process associated with cancer drug discovery and development.
On the other hand, quinalizarin has been exploited in cancer research, being effective in different types of tumor cells (breast cancer [ 8], prostate cancer [ 9], and leukemia T cells [ 10]) and angiogenesis [ 11].
This feature is exploited in cancer therapy, as inhibition of transcription and/or translation can rapidly diminish Mcl-1 levels in cells the survival of which mainly relies on Mcl-1 expression.
Together, these data define a novel, conserved mechanism to attenuate or enhance ligand-mediated Notch signalling activity that may be exploited in future cancer therapy.
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