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Functional divergence can be explicitly tested by comparing the fit of a model allowing for functional divergence versus a null model in which functional divergence is not permitted (θ = 0).
Our network model can be explicitly tested by administering a high-dose of SS while activating or inactivating part of the network, such as the PFL, and determining if the manipulation abolishes tinnitus or hyperacusis or alternatively determining how such manipulations affects the electrophysiological and fMRI properties of the network.
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This was explicitly tested by plotting the proportion of embedded quartets in agreement, against the proportion in disagreement with the groups inferred from the phenotypic data (Figure S2; see methods for group demarcation; [46]).
The plausibility of an isolation-by-distance scenario was explicitly tested by Mantel's tests in ARLEQUIN to analyze the relationships between genetic (mean number of pairwise nucleotide differences, Φst) and geographical (straight line differences) distances between sampling localities.
To this aim, rat recognition of the transformed prototypes (i.e., those same object views that had been used as primes in the priming experiment) was explicitly tested, by presenting these conditions in regular trials and providing feedback to the animals about the correctness of their responses.
The possibility that such a manipulation exists in this system, as suggested by the proteome expression evidence, can be explicitly tested.
This will be explicitly tested in the planned demonstration.
A pattern of isolation-by-distance was explicitly tested using Mantel tests to compare pairwise geographic and genetic distances between populations.
However, the specificity of the oligomerization by LTTRs has not been explicitly tested.
Most of these interactions are probably shared by both muscle actinin isoforms, though this has often not been explicitly tested, nor have actual binding affinities been compared.
In order to optimally address this concern is to explicitly develop a behavioral endophenotype of the mouse model in which the mouse is explicitly tested using tasks rigorously designed to explicitly test the cognitive domains affected in the clinical population.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com