These precounselling factors should be explicitly addressed in the genetic counselling protocol, and should be a guiding element in the process of providing information.
Although we strongly feel that intrahost genetic diversity or transmission bottlenecks do not need to be explicitly modeled in our submitted work, we now explicitly state our assumption of a genetically homogeneous intrahost viral population (i.e., we explicitly state that we do not incorporate intrahost influenza genetic diversity in our models).
For this purpose, we use a simple two-component model of a genetic toggle switch, whose potential landscape can be explicitly visualised.
Intriguingly, a recent survey of skull and dental morphology of museum specimens suggested that some observed craniofacial anomalies may represent the outcome of secondary admixture between separate populations in both western and eastern gorillas, but this scenario has not yet been explicitly tested with genetic data [ 18].
The genotypic values, which are explicitly defined in the genetic model approach, instead become emergent properties of a biologically interpretable dynamic system.
Genetic testing is explicitly regulated in the Netherlands 18; therefore, it is to be expected that smokers perceive less disadvantages of genetic testing than smokers in other countries were regulation is less explicit.
Therefore genetic data is explicitly linked to morphological specimens, which are stored in a zoological collection.
Furthermore we retained only variations for which a bibliographic reference reporting the association to a genetic disease is explicitly indicated in UniProtKB.
In some countries, genetic testing is explicitly regulated with regard to all aspects (eg, Austria, the Netherlands and Norway); in others; the regulation has focused only on the insurance industry (eg, Denmark and Sweden) or even only on group health insurers (eg, USA).
In addition, recurrent mutation as a cause of persistent polymorphism was considered most unlikely and, in fact, this evolutionary cause is explicitly excluded from the definition of genetic polymorphism by Ford (see above).
