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How can activity differences be explained for samples that appear the same by ensemble techniques such as NMR? Mechanistic understanding of multivalent behavior allows for the design of new conjugates with optimized behavior but, to date, has remained a significant challenge for the field.
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There were also a high percentage of females in the sample, which can be explained for two reasons.
This was explained for 54 samples by low amplicon concentrations observed before pooling (< 1 ng/μl) and probably resulting from poor DNA conservation.
The large variation may be explained by sample selection or by the methods applied for assessing SMC [ 1].
The observed heterogeneity could be explained by larger sample size for the LUAD dataset, this reasoning is not true for COAD that in spite of having around 2/3 of the samples in the PRAD dataset (Supplementary Table S1) results in higher number of high scored PIGs.
That there were weaker associations between FENO and personal PM or BC may be explained by small sample air volumes, especially for the 4 L/minute personal PM10 samples, and the higher relative measurement error for these samples.
The low p,p′-DDT levels in 2010 can partly, but not fully, be explained by low sample volumes perhaps insufficient for such sensitivity of the analytical instrument.
What little correlation is observed for flies can apparently be explained largely by greater sampling error for highly expressed proteins because they tend to evolve more slowly, as demonstrated by the sampling analysis shown in table 3. Thus, despite the fact that expression level is the best known predictor of ER, it does not correlate strongly with the tendency of that rate to fluctuate.
This may be explained in that the sample size for squamous cell carcinoma subtype was small.
Differences between the two 800-mg dose groups could be explained by the longer sampling interval for the biweekly-dose group.
This may be explained by the small sample sizes for some of the studies and the low power to detect anything other than large differences in the mean changes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com