This can be explained by variant of water saturation.
Furthermore, if much of the genetic variance of interest is explained by variants in or near transcribed genes, then these markers may be more efficient than randomly distributed markers.
We used a variance component analysis to determine how much variance can be explained by the variants in each class, over and above the same number of randomly chosen intergenic variants.
There is sustained debate between those who believe the missing disease contributions will be explained by rare variants with a large effect or common variants with small effects.
On the other hand, a significant amount of phenotypic variation can be explained by common variants, as long as genome-wide SNPs are jointly analyzed (Yang et al. 2010; Zhou et al. 2013).
The so-called 'missing heritability' may be explained by common variants with very small effects and/or by rarer variants with larger effects, neither of which can be identified by current genome-wide association studies.
To estimate how much of the variance for ASD can be explained by common variants, the allele score derived from the Stage 1 data (21) was used to predict case status in the Stage 2 data and calculate the VM.
Indeed, for Crohn's disease, it has been estimated that 22% of the differences in individual disease risk seen in the population (variance in disease liability) can be explained by common variants tagged on microarrays [63] – more than double that explained by known risk loci [64].
In general, only 1.5%50%% of heritability of common complex diseases and traits can be explained by common variants [16].
To what extent the genetic component of T2D can be explained by common variants relies upon the shape of the genetic architecture of T2D.
