Sentence examples for be explained by targeted from inspiring English sources

This phenomenon may be explained by targeted mediated-drug disposition and high levels of TNF-α (which corresponds to antigenic burden) binding infliximab, which influence its pharmacokinetics.

There have been arguments, however, that the observed declines in HIV prevalence among antenatal women in Avahan covered districts in Karnataka state are unlikely to be explained by targeted interventions alone [ 28].

The observed variability in response to different probes of KCNMA1 might be explained by target specificity, and the functional interplay between these and other genes in the cell lines studied.

route of vaccination may be explained by direct targeting of antigen presenting cells (APCs) in the dermis and epidermis.

While targets and pathways downstream of oncogenic fusion proteins provide a wealth of therapeutic targets in Ewing sarcoma [226], the clinical benefits from targeted therapy have been limited, and not always been explained by target expression  [242], [253].

In animals, miRNAs are thought to regulate gene expression by mediating repression of protein synthesis and/or destabilization of mRNAs [5], although recent studies have indicated that in the majority of reported cases, a reduction in protein synthesis can be explained by direct down-regulation of target mRNA levels [6], [7].

Their method revealed that only 48% of targets could be explained by direct binding of the profiled transcription factors, while 16% could be explained by indirect binding.

As mentioned earlier, the explanation inference concerns the extent to which test performance can be explained by the targeted construct of pragmatic comprehension ability.

The apparent discrepancy may be explained by genes targeted by p53 under different circumstances, resulting in different cell fates.

Next, we focused our attention on those miRNAs that reduced Akt activation because their effect can be explained by the direct targeting of key players within the ErbB-Akt pathway.

This phenomenon can be explained by the direct targeting of miR-146a to the signal transducer and activator of transcription 1 (STaT1), a key transcription factor in IFN- γ response and in Th1 differentiation [ 21].