Sentence examples for be explained by systemic from inspiring English sources

It was speculated that this phenomenon could be explained by systemic inflammation and/or through high dose systemic corticosteroid treatment [ 49].

Threshold robustness in gene regulatory networks illustrates that hidden genetic variation can be explained by systemic properties of the genotype-phenotype map.

A subgroup analysis suggested reduced efficacy of tofacitinib with increasing body weight; however, it is unclear whether this trend could be explained by systemic exposure alone.

However, since exposure did not parallel the efficacy weight relationship, it is unclear whether the possible trend toward lower PASI75 and PGA responses with higher body weight could be explained by systemic exposure.

Inasmuch as the cellular composition of liver slices is comparable to the liver in vivo, i.e. both models contain parenchymal and non-parenchymal cells [ 40], these differences may be explained by systemic effects that are obviously absent ex vivo.

Conflicting data has been reported that suggests different efficacy of the drug in different populations, which may be explained by the systemic exposure to the drug.

They may partly be explained by concomitant systemic inflammation, which can affect TIMP-2 and IGFBP7-production [ 18].

We consider it unlikely that this apparent discrepancy might be explained by merely systemic differences between mammals and teleosts: given the conserved function of the Tie-1 and/or Tie-2 signaling axis in mammalian and zebrafish heart development, it seems unlikely that other aspects of Tie-2 function would diametrally diverge.

It can be explained by relatively high systemic venous pressure in Fontan circulation, preventing the development of large extrahepatic portosystemic collaterals.

These changes might be explained by the increased systemic free fatty acid exposure caused by impaired capacity of fat tissue to store lipid.

A correlation between presepsin and inflammatory biomarkers, such as CRP, WBC, IL-6 and PCT, can be explained by the ongoing systemic activation of inflammatory biomarkers during severe sepsis and septic shock [ 3, 24].