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This may be explained by sequestration of active TGF-β in lesional tissues such as the skin caused by upregulation of various TGF-β binding proteins, many of which are TGF-β inducible.
A large number of biochemistry-based investigations concluded that miRNA-associated mRNA destabilization was concurrent with translational inhibition at the initiation stage 10, 18– 20, and that this could be explained by sequestration of mRNAs inhibited by miRNAs to the P-bodies, where the silenced mRNA would be degraded 21, 22.
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This elevated rapid ERK activation may be explained by longer sequestration of MIF on the cell surface after CPZ treatment.
In our data, the presence of untranslated FGF2 mRNA after 3 h of hypoxic stress (Fig. 4B) could be explained by its sequestration in stress granules.
However, we have also observed cytoplasmic staining, which could be explained by cytoplasmic sequestration of cyclin D1 due to inhibition of its transportation to the nucleus (51, 52).
The reductions in concentrations of amino acids such as cysteine, isoleucine and alanine and vitamins (A and E) may be explained by instability, degradation, circuit sequestration or oxidative mechanisms [22].
The decrease of sequestration would be explained by the steric hindrance around the cationic charge of the polymer.
Our human volunteer studies have now revealed two instances of non-destructive sequestration that might be explained by low-affinity IgG-FcγR interactions.
No sex differences were found what may be explained by the lack of diet differences and/or low sequestration of the surplus of non-essential elements in females to the eggs during their formation.
The intensity of tissue specific sequestration within the eye might be explained by the distribution of endothelial receptors in different vascular beds.
Increased protein levels were independent of protein production, sequestration or impairment of autophagy but can be explained by UPS compromise.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com