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The low prevalence in Dutch hospitals can be explained by restrictive antibiotic use and our national "search-and-destroy" policy [ 3], which requires that patients who are repatriated from foreign countries, contacts of MRSA patients, citizens and patients from abroad are strictly isolated at hospital admission until screening cultures for MRSA prove negative.
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This could partly be explained by more restrictive prescription of hormone replacement therapy according to new guidelines [ 32].
The remaining proteasomal processing of Def1 observed in this experiment might be explained by residual Rsp5 activity at the restrictive temperature, or by ubiquitylation merely playing a stimulatory role in Def1 processing.
These specificities may partially be explained by a selection bias due to restrictive inclusion criteria, which excluded the most severe individuals (baseline EDSS scores higher than 7.0) and included a high proportion of patients treated with disease modifying therapies (95%).
These findings can be explained by external and situational/interactional influences, such as restrictive environments, which increase the likelihood of frustration and the possibility of aggression [ 1].
The contribution of heart failure to restrictive lung disease may be explained by the increased heart size in a fixed thoracic cavity thus reducing the functional lung volumes [ 64].
This can be explained by a general result according to which CW is a more restrictive standard than TW.
The association between lung disease and infection in our cohort could be explained by the frequent occurrence of serious respiratory infections in patients with restrictive disease (six out of 14 patients).
These findings could be explained by discrepancies in trials, notably regarding the approach to treat hyperglycemia: high versus restrictive caloric intake.
(3) Physicians seem to have a less restrictive attitude towards continuation of treatment than nurses, which could partly be explained by nurses having a better understanding of their patients' feelings.
This could be explained by the limitations of the TRICC study [ 9] that may hinder the adoption of the restrictive transfusion strategy in all ICU patients.
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