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The latter option may be explained by redundancy mechanisms.
High diversity of the latter three regulons can be explained by redundancy of the respective metabolic systems and regulatory mechanisms.
Likewise, changes in within-module interactions can result in functionally similar modules, and can be explained by redundancy or indirect interactions via a third protein, as long as the two proteins remain in the same module.
A MMP-9 knockout mouse exhibited no or modest structural/functional abnormalities, both on a healthy background and in a model of Alport syndrome [ 40], which could be explained by redundancy of the system based on observations of compensatory upregulation of other MMPs, including MMP-2 [ 41].
However, the milder phenotype observed in the embryonic lung of Hmga2-KO mice when compared either with the Gata6-KO or the phenotype induced after Hmga2-KD in embryonic lung explants might be explained by redundancy in the function between Hmga2 and Hmga1, another member of the HMG protein family.
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Minor alterations in neuronal circuits in these mutant animals are explained by redundancy and/or adaptive changes of other genes relevant for brain development.
Partial derepression could be also be explained by functional redundancy by related Ring1a, which possess ubiquitin E3 ligase activity towards histone H2A, alike Ring1b, although with less efficiency [56] [58].
Notably, only mild alterations in dopaminergic neurotransmission have been observed, but no degeneration of dopaminergic neurons, which might be explained by functional redundancy or compensatory mechanisms [6], [7], [8], [9].
To address if the lack of a T cell phenotype in PTPN3-deficient mice can be explained by functional redundancy of PTPN3 with PTPN4, we generated PTPN4-deficient and PTPN4/PTPN3 double-deficient mice.
We further asked if the absence of a T cell phenotype in PTPN3/PTPN4 double-deficient mice could be explained by functional redundancy with PTPN13, which also contains FERM and PDZ domains, albeit that this PTP shows a low degree of homology to PTPN3 and PTPN4.
This could be explained by functional redundancy or the difficulty in isolating gametophytic mutants.
More suggestions(15)
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