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In this way, transcribing region conservation could be explained by purifying selection, as suggested by Nei and Rooney [ 10].
Under these scenarios, the high sequence similarity can be explained by purifying selection that maintains sequence identity within tRNA families.
The enrichment of 3 n coding indels compared to 3 n genome-wide indels may be explained by purifying selection against frameshifts in coding regions.
Alternatively, the lack of MHC variation could be explained by purifying selection for alleles advantageous against a current parasite or a past selective sweep [ 37].
The lower diversity may be explained by purifying selection acting upon the transcribed genes, resulting in relatively more conserved genetic regions (see Bouck and Vision 2007).
This can be explained by purifying selection that not only maintains the primary structure of the protein, but also affects the spatial arrangement of crosslinking regions (i.e., the main components responsible for elasticity).
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This was explained by purifying selection forces acting to conserve both the peptide and DNA sequences.
Although both these works observed a depletion of variability in Africans in comparison to Europeans and Asians, which was explained by purifying selection in Africans, the interpretation for the enhanced Euro-Asiatic diversity was different.
First, this pattern could be explained by relaxed purifying selection on chemosensory genes.
We note that d N/d S values > 1 could also be explained by relaxed purifying selection.
Although low divergence can also be explained by strong purifying selection, these two phenomena can be distinguished by comparisons across species.
More suggestions(15)
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