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The remaining 5 novel peptides (Table 3) displayed some weak similarity (expectation value>1) to human peptides, raising the possibility that some of the peptides could actually be explained by polymorphisms.
Some of the variability seen in this study may be explained by polymorphisms of genes involved in antioxidant defenses, many of which vary by race/ethnicity.
The clinical variability in our classical WHS patients could be explained by polymorphisms in the 4p alleles present plus multifactorial inheritance patterns.
> While most of the polymorphisms introduced above may be associated with type A (aggravated, overdose-like) adverse drug reactions, type B (bizarre, idiosyncratic, mostly allergic) adverse drug reactions may be explained by polymorphisms in genes of the major histocompatibility complex.
This might be explained by polymorphisms observed in this paralog that result in mis-sense changes in amino acid residues conserved between all grass GA3ox sequences (Additional file 1: Figure S9), but technical problems with heterologous expression cannot be ruled out.
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In adult Caucasian patients, over 40%% of the inter-individual variability in dose is explained by polymorphisms in two genes, VKORC1 and CYP2C9 [ 4].
While little variation in metformin plasma pharmacokinetics was explained by polymorphisms in OCT1, polymorphisms in that gene appeared to modulate appeared to modulate the access of metformin to its target sites in the liver cell [ 63].
This variability can be explained by genetic polymorphisms characteristic of each patient.
To investigate whether interindividual variation in CYP3A levels can partly be explained by genetic polymorphisms, this study was designed to phenotype 200 healthy Bangladeshi subjects by measuring urinary ratio of 6β-hydroxy-cortisol/cortisol and to genotype all the subjects for the presence of CYP3A4*1B, *2, *4, *5, *6, *10 and *18 and CYP3A5*3 alleles.
The presence of haplotypes shared with chickens can be explained by ancestral polymorphisms and/or introgression.
Additionally, the efficacy of Ab treatment can be explained by FcR polymorphisms.
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