Besides, odds ratio values are corrected for G+C content and, consequently, dinucleotide biases found using this metric cannot be explained by background nucleotide composition.
The observed excess of GT>GC conversions hardly can be explained by a nucleotide substitution bias.
These shifts can be explained by single nucleotide substitutions at the 86 and 90 spectral tuning sites found in the partial sequence of OPN1sw1 across birds in a past study [ 15].
The disparate association of ras mutations with melanoma in humans and Monodelphis may be explained by differences in nucleotide sequence at codon 61 of the N-ras gene as well as differences in skin architecture between the two species.
This increase cannot simply be explained by biases in nucleotide composition, and remains statistically significant when controlling for phylogenetic non-independence.
This might be explained by chromosomal deletion, nucleotide polymorphisms in the sequences complementary to PCR primers [ 23], or insufficient DNA quality.
The sequence of the latter taxon is most similar to that of A. fulgens, and its distant position to this species in fig. 1 can also be explained by several missing nucleotides.
The absence of any effect with oxaliplatin-based therapy as a single agent may be explained by DNA repair mechanisms by nucleotide excision repair that are adequate for singular oxaliplatin therapy but inadequate in the face of combination therapy.
For a given sequence and word, we estimate a p-value for the null hypothesis that the number of observed word occurrences m can be explained by the length and nucleotide composition of the sequence.
