Sentence examples for be explained by mutation from inspiring English sources
The alternative view, applicable to characters other than body size or wing length, is that patterns of evolutionary change can either be enabled or directed by the mutational process itself and thus properly be explained by mutation rather than natural selection.
If the frequency of two or more discontinuous forms within a species is too high to be explained by mutation, the variation as well as the population displaying it is said to be polymorphic.
As the divergence between D. melanogaster and D. simulans does not follow this pattern, the drop in variability cannot be explained by mutation rate variation, but is attributed to selection [27], [28].
Cancer recurrence also cannot be explained by mutation theory.
Thus, cancer incidence patterns across lifespans cannot be explained by mutation accumulation alone, regardless of the type of cancer or organism studied.
A linear regression of AT skew on mutation position indicates significant positive correlation for normal genomes, though only a small proportion of compositional variation can be explained by mutation position (y = 0.000006874 x + 0.271, r2 = 0.056, P < 0.001).
To determine the percentage of cases with CAKUT that can be explained by mutations in known CAKUT genes, we analyzed the coding exons of the 17 known dominant CAKUT-causing genes in a cohort of 749 individuals from 650 families with CAKUT.
Although part of the cases can be explained by mutations that lead to a non-functional and/or truncated CSA protein, it remains to be established how a group of single missense mutations can give rise to CS. Importantly, the majority of these mutations are present in the WD40 repeats of CSA that we discovered to be important for the interaction with TRiC (Fig. 2 and Supplementary Fig. 4a).
The absence of miR-137 in 501mel cells might be explained by mutations in the miR-137 gene itself as has been shown to be the case in other melanoma cells [31], thus allowing high levels of MITF expression.
On the contrary, it has been argued that mutator mutations (MM) are unnecessary for cancer development, and that the observed incidence rates of cancer may be explained by mutations occurring at the normal rate in conjunction with multiple rounds of lineage expansion and selection [11] [14].
