These findings may either be explained by intra-tumor heterogeneity as suggested by Platt et al., or that the biological consequences of activating FGFR3 and RAS mutations do not overlap completely and therefore double mutants may result in an additive but small selective advantage.
This result can be explained by intra-individual variability in the perception of disease and health status.
Therefore, the reason why the LBW affects the progression of CKD can be explained by intra-glomerular hypertension, which is induced to compensate for the small number of nephrons [ 13- 15].
The occurrence of the S. mordax morphotype in both species B and C can hardly be explained by intra-specific variation alone, but may rather result from phenotypic convergence (whereby two non-sister species independently evolve similar morphologies) and/or morphological stasis (whereby the appearance of the common ancestor of two sister species is passed on to both of them).
Instead, it is reasonable to assume that the functional deficit observed in this cohort of patients can be explained by intra-retinal, subcortical and cortical neuronal disorganization or injury related to PD. Animal and human studies have suggested the involvement of the visual pathway in the disease process of PD [ 31, 32].
This pattern is well reflected by extensive overlap of groups in the scatter plots for both call types and shows that most variation in both call types is explained by intra-specific variation.
Mammalian Tim has been best characterized for its function in monitoring replication fork stability in S phase, but other functions of Tim can not easily be explained by its intra-S phase functions alone.
These results may be explained by an intra-species synergy between the two types of brain cells.
Our findings may be explained by suboptimal intra-abdominal infection management or inadequate antimicrobial concentration in these patients.
However, the difference in ETP between smokers and non-smokers was only minimal and could be explained by the intra-assay variation of the CAT assay.
