The search procedure is explained by example in Supplementary Figure S2.
The steps required in preparing this complex dataset for analysis (transform, account for death, impute missing data – "tdi") are explained by example here, and in more detail in Appendix 1.
This makes it possible to distinguish differences that reflect a disagreement on the underlying biology (case studies I-III) from differences that may be explained by, for example, different decisions taken on how to represent knowledge (Table 2).
This might be explained by, for example, a changed surface/volume ratio or changes in the light environment and in air water exchange processes.
Possibly, the relatively high amount of synthesized CD44 protein in MDA-MB-361 can be explained by for example post-transcriptional modifications and translational regulation specific only for this cell line.
The differences might be explained by, for example, dissimilarities in health care systems in different countries and restricted empirical testing of explanatory models [ 9, 10], which further emphasizes the need to avoid crude generalizations about people's beliefs and instead to probe for and verify the individual's own perspective.
This finding may be explained by, for example, variable concentration of antigens on the bead, differences in antigen molecule structures and orientation on the bead surface and/or the affinity between non-specific antibodies and the unoccupied bead surface or coupled antigens.
As it is probably the case for our study system, different steps of the infection process might follow distinct evolutionary dynamics and be explained by different model (for example, balancing selection, directional selection) [ 10, 11].
Several documented examples could be explained by this model.
