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Our results therefore further support the notion that pharmacoresistance in schizophrenia might be explained by enhanced P-gp expression lowering the brain accumulation of antipsychotic drugs.
Given these findings we hypothesized that the THC-induced reduction in brain risperidone and active metabolite concentrations might be explained by enhanced P-gp expression at the BBB.
Considering these findings, we hypothesized that the THC-induced reduction in brain risperidone levels might be explained by enhanced expression of the ABC transporter P-gp.
The decrease in Voc can be explained by enhanced non-radiative recombination via Cu trap levels in the middle of the band gap.
The higher late Pleistocene erosion rates are largely unrelated to glacial erosion and could be explained by enhanced sediment production on steep hillslopes due to increased periglacial activity that declined as temperatures increased.
The greater potency of NMDA in kindled rats can probably be explained by enhanced expression of NMDA receptors in the presence of a receptor reserve.
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This behavior was explained by enhanced ionization of the background in a system of crossed electrical and magnetic fields.
The obtained result is explained by enhanced dye-loading (1.055 × 1017 molecule/cm2) and improved charge transfer resistance (Rct = 9.18 Ω) of the photoanode substrate.
The transient current increase was explained by enhanced production of soluble intermediates, while increased production of adsorbed CO poisoning explained the slower inhibition.
A drop in the thermal and electronic conductivities are explained by enhanced scattering of the electrons by solid solution Mg in the aluminum metal.
The enhanced catalytic activity of A-I-Pd/C is explained by enhanced kinetics of oxidation of Hads, which is caused by weaken adsorption strength of Hads on Pd due to electron transfer from H to Pd.
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