Whereas the occurrence of limping may be explained by the presence of a deficient trochanter with impairment of the abductor apparatus, this appears to be less evident with the use of a BS-ring.
Given the role of MSH2 in DNA repair, it was also possible that the methotrexate sensitivity observed in MSH2 deficient cells could be explained by mutations that occur secondary to MSH2 deficiency and not MSH2 deficiency per se.
To address if the lack of a T cell phenotype in PTPN3-deficient mice can be explained by functional redundancy of PTPN3 with PTPN4, we generated PTPN4-deficient and PTPN4/PTPN3 double-deficient mice.
However, these findings can be explained by the fact that MyD88-deficient mice suffer from a higher spirochetal burden than WT mice.
This difference in CNAs profiles might be explained by the need for BRCA1-deficient tumor cells to acquire survival factors, by for example specific copy number aberrations, to expand.
We speculate that the inability of SMCs or cIAP1 knockdown to recapitulate the previously reported function of cIAP1/2 in NOD2 signalling, might be explained by the fact that cIAP1-deficient mice carry a passenger mutation inactivating caspase 11 (Kenneth et al, 2012) or possibly by different roles for cIAPs in murine and human cells.
Parts of this effect could be explained by the higher accessibility of CIX-deficient cartilage for binding of arthritogenic CII-specific antibodies.
The FA pathway-deficient cells are also hypersensitive to Chk1 silencing, 100) which may be explained by the hyperdependence of the FA pathway-deficient cells on G2/M checkpoint activation mediated by Chk1 for viability.
This sequence of events in the CF lung might be explained by an impaired protection of the QS deficient strains against the mutagenic effects of reactive-oxygen species liberated by activated PMNs due to their decreased production of catalase and superoxide-dismutase.
