Sentence examples for be explained by defective from inspiring English sources

The loss of inhibitory synapses also cannot be explained by defective TrkB signaling in interneurons themselves (Rutherford et al. 1997, 1998; Swanwick et al. 2006) as they do not express the transgene in TrkB.T1-broad mice.

However, Pol κ differs from the three other Y-family human DNA polymerases in that mice lacking Pol κ exhibit, besides a spontaneous mutator phenotype which could be explained by defective TLS across endogenously generated adducts (Stancel et al, 2009), increased tandem repeat mutations (Burr et al, 2006) suggesting that Pol κ could have other roles in addition to TLS.

Class II MHC molecules are involved in antigen presentation to CD4 helper cells, and the associations outlined above are likely to be explained by defective affinities to islet cell antigenic peptides, leading to persistence of T-helper cells that escape thymic ablation.

Therefore, to determine whether the paucity of osteoclasts in bones of ptpn11 fl/fl ert2-cre mice could be explained by defective osteoclastogenesis, and at the same time understand whether any defective osteoclastogenesis were intrinsic to the hematopoietic compartment, we examined osteoclastogenesis in vitro.

They may be explained by a defective glucose counter-regulation in type-1 diabetic patients caused by frequent hypoglycemic episodes called "hypoglycemia-associated autonomic failure".

This decreased proliferation might be explained by a defective expression of costimulatory molecules in the Jak3−/− DCs and/or to decreased DCs cytokine production.

This can be explained by their defective homologous recombination pathway, a DNA repair mechanism in which BRCA-proteins have a major role.

This finding could be explained by a possible defective cell-mediated immunity against HPV induced by tobacco [ 37].

Safety Research, which in the past has advised consumers suing Toyota, goes a step further and contends that the N.H.T.S.A. is ignoring acceleration complaints that cannot be explained by driver error or defective floor mats and pedals.

But as the calf was the result of artificial breeding between genetically related and phenotypically normal animals and as it was the only affected calf occurring in a herd of 96 adult females, such an incident could be explained by transmission by descent of a defective recessive allele from a common ancestor.

Both of these features could be explained by the action of a relatively large defective interfering particle population [43], [44] within the viral stock, which is not uncommon for the influenza virus [45].