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Some of these effects can be explained by currently understood mechanisms.
Recent estimates suggest that ˜14.4% heritability of AD can now be explained by currently reported loci.
The number of common variants that account for more than 1% of inherited risk is very low and only a small proportion of the heritability of any cancer can be explained by currently identified loci.
In the revised version of the manuscript, we have paid particular attention to carefully word our interpretation of this result since it cannot be explained by currently known signaling mechanisms.
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Out of the DDIs predicted by network expansion procedure, ∼16.67 51.89% cannot be explained by the currently available PPI datasets, suggesting that there could be PPIs mediated by these novel DDIs that may not been discovered yet.
However, many of these polymorphisms have not been definitively associated with altered DPD activity, and not all toxicity to 5FU from reduced DPD activity can be explained by the currently known DPYD polymorphisms.
Objectives To examine the relation between area level social deprivation and ultrasound markers of atherosclerosis (common carotid intima-media thickness and plaque score), and to determine whether any differences can be explained by "classic" (currently recognised) or "emerging" (novel) cardiovascular risk factors.
The study is refreshing, he says, because "the pathology of MS can't be explained by what we currently know".
This discrepancy could be explained by the different climate currently found in the two areas: temperate Mediterranean in Italy and temperate oceanic in New Zealand.
Whether this association might in part be explained by common pathophysiologic pathways currently is unknown (e.g., the GIGYF2 gene involved in both IGF and insulin-signaling pathways recently has been identified as the PARK11 gene, but current literature does not provide strong support for its role in Parkinson's disease).
Nevertheless, despite the progress in asthma pharmacogenetic research, only a small percentage of the variability in treatment response can currently be explained by variations in SNPs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com