Sentence examples for be explained by copy from inspiring English sources

This result demonstrated that the variations in expression level could not be explained by copy number alone, and thus differential transcription modulation or post-transcription processing should be considered.

Having observed that copy number variation explains the coarse-scale profile of WCEseq libraries, we asked whether there exist finer-scale irregularities beyond what can be explained by copy number.

Hence, a substantial 'missing heritability' (10) becomes obvious, which might in part be explained by copy number variants (CNVs).

CCND1 is a firmly established oncogene that is often overexpressed in primary breast cancers [ 15], and while aberrant overexpression of CCND1 is often due to gene amplification, up to 50% of breast cancers display increases in CCND1, many of which cannot be explained by copy number variations, indicating that alternative mechanisms such as transcriptional dysregulation must be involved [ 16].

The DNA methylation level of the three CTCF binding sites was not as high for PCC samples as for ACCs (P=0.022, Mann Whitney test) and this difference could neither be explained by copy number changes nor content of tumor cells in the samples.

After this had happened, a duplication event within a telomere could potentially be explained by copying from one telomere to another (i.e. copying from the new telomeric site back to the original telomeric site where the construct remains or vice versa).

The correlation was represented as R2 to see the extent to which the variation in RBP expression can be explained by DNA copy number alterations at the RBP locus.

(A ) Models for the interpretation of EMSA results shown here and in Figure 2. (I) The multiple shifted bands can be explained by multiple copies of SCML2 fragments binding to a single RNA molecule or nucleosome.

Further, Sunde and colleagues found a significant correlation between gene copy number and EVI1 gene expression, and suggested that enhanced expression of EVI1 can partly be explained by increased gene copy number [ 31].

Nearly 80%% of transformant GA activity varied within a range of 15 20 %, which could be explained by a single-copy integration of the GA fragment at the engineered locus.

We examined whether the relatively elevated expression of the four genes identified in our RNAi screen could be explained by changes in gene copy number (i.e. copy number gains and/ or gene amplification).