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More than a fifth of the weight differences between people can be explained by common "obesity genes", according to research that confirms some people are naturally at greater risk of becoming overweight.
In general, only 1.5%50%% of heritability of common complex diseases and traits can be explained by common variants [16].
To what extent the genetic component of T2D can be explained by common variants relies upon the shape of the genetic architecture of T2D.
This effect may be explained by common exposures of household members to local risk factors.
This may be explained by common minor exposures which are being ignored.
These observations may be explained by common features in the pathophysiologies of CKD and type 2 diabetes.
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"I suspect that this paper on its own will not completely settle in many people's minds how much 'missing heritability' is explained by common variation," says Joel Hirschhorn, a geneticist at the Broad Institute of the Massachusetts Institute of Technology and Harvard University who carried out one of the studies of height.
Communality is the proportion of variance in that variable which is explained by common factors.
Ever since Darwin, homology in biology has been explained by common descent.
It is now estimated that 28% of familial breast cancer risk is explained by common breast cancer susceptibility loci.
Approximately 60% of this overlap is explained by common genetic effects, with 40% of the overlap due to environmental experience.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com