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In other words, the difference in concentrations of antibody detected after immunizations of wild-type and 3xTg-AD mice cannot be explained by binding of antibody to circulating plasma Aβ molecules.
Biotin-VAD-FMK binding could not be explained by binding to caspase(s), as caspase genes are absent in these organisms.
For 5-HT, a significant reduction of resonance intensities was observable only after 48 h, which can be explained by binding of 5-HT to accumulating aggregates rather than to monomers.
Yet, a significant proportion of experimentally identified binding sites that are conserved in closely related species are absent in distantly related species and so cannot be explained by binding site turnover.
By searching orthologous intergenic sequences for a small set of a carefully defined transcription factor binding sites as well as for a larger set of sites defined by chromatin immunoprecipitation experiments in S. cerevisiae, we show that a substantial fraction of binding sites are absent in distantly related species and so cannot be explained by binding site turnover.
Therefore, our data suggest that daunorubicin may target the cAMP signalling pathway of yeast, inhibiting expression of many regulated genes and particularly those under control of Cst6p, ant that may be explained by binding of the drug to the Cst6p DNA recognition site.
Similar(51)
The rates for active K+ uptake in the absence of ouabain (~280 nmol/min per mg protein) are consistent with previously observed rates of K+ uptake in similar cultures [ 31] and the biphasic effect is explained by binding to two different Na+,K+-ATPase subunits [ 50].
Indeed, a recent analysis of yeast ChIP-Chip data revealed that only 48% of detected transcription factor binding sites could be explained by direct binding and an additional 16% by indirect binding [ 28].
We show here that the new results can be explained by incomplete binding of utrophin to actin, heterogeneity in the mode of binding, and angular disorder in F-actin.
Their method revealed that only 48% of targets could be explained by direct binding of the profiled transcription factors, while 16% could be explained by indirect binding.
This attenuation may be explained by chloride binding and scattering.
More suggestions(15)
be visualized by binding
be purified by binding
be decided by binding
be killed by binding
be affected by binding
be caused by binding
be achieved by binding
be supplemented by binding
be enhanced by binding
be inactivated by binding
be inhibited by binding
be stimulated by binding
be released by binding
be altered by binding
be stabilized by binding
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