Because the seven cryptorchid boys, who all had exposed mothers, were omitted from the multivariate analysis, the observed differences cannot be explained by altered hormone concentrations and impaired gonadal development in cryptorchid boys (Main et al. 2006a; Suomi et al. 2006).
It is explained by alter vasoconstrictive/vasodilatatory function, by triggering inflammatory processes (through NO and adhesion molecules such as ICAM-1, VCAM-1, and E-selectin) and by affecting haemostasis (through release of tissue factor, von Willebrand factor, thromboxane A2, and fibrinogen) [ 6].
Even if our data do not confirm all presumptions of the ceiling theory, we found and altered information processing which presumably can be explained by an altered preactivation level.
There are 22 genes with stage-dependent expression alterations that cannot be explained by CNV, altered methylation, or dysregulated transcription, which suggests that other regulation programs responsible for expression alterations in the late stage are not included in the model.
This may be explained by an altered kinetics in knockdown cells, since when CHC is reduced, endosomes appear closer to the Golgi apparatus [39], [40].
The observed AMPK-mediated boost of XN-induced Nrf2 signaling cannot be explained by an altered cellular redox balance.
This could be explained by the altered gut microbiota composition or by the decreased food intake observed at the end of the treatment, which could have lessened the substrate supply.
This finding could be explained by the altered metabolic status characterizing the SGA and LGA populations, due to the adaptive responses and the pathophysiological alterations that occur during intrauterine life (13, 14).
This dual effect of EGF could not be explained by an altered expression and/or altered functionality of the EGF receptor, as addition of EGF induced EGFR phosphorylation and internalization in both types of colonies (Fig 1C).
