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Such small numbers of false positive differences can be expected when comparisons are made for over 28,000 CpG islands and about 20,000 Refseq promoters.
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Prospective validation was lower on an average (58%), but more heterogeneous among samples, in the independent PM RM comparison, as might be expected when dealing with cases at variable risk.
What could be expected when combining logics?
Two numerical examples are provided to show the improved impact-resistance of a nuclear containment building that is expected when applying FRC in comparison with ordinary concrete.
This low percent overlap between in silico and in situ comparisons is expected when breast tissue specific expression signatures filtered for histological and molecular subtypes are used to interrogate the potential interactions between miRNA-mRNA.
However, more features were expected when analysing the BD nonpolar fraction with RPLC in comparison to HILIC.
Thus, when implemented, this set can be expected to facilitate meaningful comparisons and ultimately provide a continuous feedback loop, enabling ongoing improvements in quality of care.
While there were some other statistically significant results, as would be expected by chance alone when multiple comparisons are made, there were no other cancer sites with consistently exceptional findings.
Table 2 shows that false positive signals would not be expected in such data sets when they are truly clonal, even if the multiple comparisons correction (Dunn-Sidak) in 3SEQ were relaxed by an order of magnitude.
As could be expected, this percentage is even higher when you only consider comparisons within the super order Eucarida (>81%) or outside the class Malacostraca (<79%).
When can decisions be expected?
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com