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Therefore, approaches that control steady state H2O2 levels, a key contributor to excessive cytokine prodcution, would be expected to normalize inflammatory responses in CF epithelial cells.
56, 68 Inhibition of DUX4-FL expression or function, if successful in patients, might also be expected to normalize proteasome function and TDP-43 aggregation.
Consequently, muscle ATP turnover rates would be expected to normalize if glycogen synthesis rates were normalized by an increase in plasma glucose concentration.
Intuitively, these dietary effects of n-3 PUFA in ADHD models like SHR would be expected to normalize both groups of neurotransmitters.
Following the proposed framework, a successful lowering of oxidative stress would be expected to normalize FA and 1-C cycle alterations and consequently improve CVD risk and clinical outcomes.
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As already mentioned, the possible "normalization" of the tumor vasculature, after repeated HBO treatment, is expected to normalize capillary permeability, and thereby prevent any increase in ECV, even though Pif is decreased.
Based on a concept of cortical hyperexcitability in migraine cathodal tDCS in migraineurs is expected to normalize the cortical excitability either (i) by prophylactic treatment in the interictal phase or (ii) by an acute treatment at the beginning of the migraine attack.
But above all, bias-controlled markers and standardized detection platforms are expected to normalize and reduce the inconsistencies across studies.
A β-directed therapeutic approaches to reduce A β levels have been and are still heavily explored and are expected to normalize signalling, at least to some extent, and thus have therapeutic potential.
We note that due to the amplification of the transcripts, the targeted transcriptome method that we have used is expected to normalize the abundance of the amplicons to a degree.
When these criteria are strictly met, this strategy would be expected to 'normalize' confounding variation due to intersample variability such as differences in PCR efficiency or loading disparity.
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