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Although this would be expected to impair copper absorption, recommended copper intakes have not risen in parallel.
Nrf2 deficiency would be expected to impair cellular antioxidant responses; however, Nrf2 deficiency in preeclamptic mice improved maternal and fetal survival, ameliorated intra-uterine growth retardation, and augmented oxidative DNA damage.
Sustained or chronic early life stress would also be expected to impair cognition [20], [24] by detrimentally affecting the development of the hippocampus [25].
Affecting proteins responsible for phagosome maturation may also be expected to impair bacterial killing.
Structural variations of the gene coding for TLR-4 would be expected to impair host responses to microbial pathogens.
In any case, ROS formation induced by these toxins would eventually be expected to impair energy metabolism.
Similar(31)
Damage to the PFC is expected to impair creativity.
Hence, the S259V mutation is expected to impair the receptor capability to effectively bind PTC and to be activated, in an indirect fashion.
Thus, RNF5 overexpression is expected to impair the ER stress response, consistent with the modification of ER stress associated chaperones observed in our mouse model.
In fact, disruption of phospholipids of the ETC is expected to impair the proton gradient, thus inactivating the synthesis of ATP [41].
It is therefore tempting to speculate that the detrimental upregulation of REST in HD neurons, which is expected to impair the identity of neurons, involves Sp1 and Sp3 functions and may be oxidative stress-mediated.
More suggestions(17)
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com