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This mechanism does not require any protein protein interactions and would not be expected to constrain the spacing and orientation of the binding sites of the cooperating TFs.
This result is not unexpected, as cell types should be stable states, and network wiring would be expected to constrain flexibility of regulatory states and thus stabilize cell types.
Rather than being the cause of the observed correlations, the decrease in dN/ dS might be a consequence of the increase in the complexity of gene regulation as regulatory elements within protein-coding sequences would be expected to constrain both nonsynonymous and synonymous sites, but might affect nonsynonymous sites more, as they also need to encode the protein sequence.
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At the same time, a decline in demand for its services because of a weaker economic outlook is expected to "constrain growth prospects".
"Subdued economic growth and pressures on household finances are expected to constrain housing demand.
Non-sanctioned auditors are expected to constrain the manipulation of extraordinary items more than sanctioned auditors are.
The findings were surprising since distant market outlets are expected to constrain consumer access to household goods (Vorster et al. 2007).
This in turn is expected to constrain intermolecular interactions in the CytR-CRP-DNA complex, thus generating operator-specific effects on repression and induction of transcription.
Rather, judges were expected to constrain the executive and legislative branches.
Gene flow can be an important determinant of geographic variation in morph frequencies (e.g. [ 11]) and is expected to constrain local adaptation by introducing individuals from populations experiencing different selective pressures [ 12, 13].
With the steady increase in dependent older population [ 1], greater demand for health services and increased health care expenditures are expected to constrain the economies of many Low and Middle Income Countries (LMICs) [ 2].
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