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If the genes tested here were expressed predominantly in response to developmental cues, it could be expected that expression of transcripts would be extremely similar across all geo-cytotypes, which is not what was observed.
In this regard, it is important to note that research on LAB expression systems is still in progress, and it can reasonable be expected that expression efficiencies of such systems will be much improved over the next years.
35 As in GC patients, miR-148a expression is downregulated (previous study) and HPIP expression is upregulated (this study); it could be expected that expression of miR-148a might be inversely correlated with HPIP expression in GC.
Strength training is associated with changes in protein synthesis and degradation, and because heat shock proteins assist in these processes it could be expected that expression of HSP would increase initially but decline in the later phase of the training period.
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Intuitively, it is expected that expression from the large parental genome would be favored because "concentrations" of cis-regulatory elements are lower in the nucleus of large genomes and competition by non-specific binding targets is greater.
It was expected that expression from chromosome would be less than from a multicopy plasmid.
It is expected that expression levels of transcripts that are direct targets of NMD should decrease rapidly.
It is expected that expression of these genes would differ between muscle, heart, and liver because of the differences in how these tissues grow.
Given these functions, it is expected that expression of these genes would decrease with age as there is less activation, proliferation, and differentiation of satellite cells and, thus, less need for the growth regulatory functions of these genes as growth slows.
For a cell cycle oscillating gene, it is expected that gene expression will peak and trough once per cell cycle, and the oscillation can be modeled using Fourier analysis [ 4].
In fact, it would be expected that altered expression of some genes contributes to the general drug-resistant phenotype seen in all colorectal adenocarcinomas, while expression of others distinguishes individual biologically distinct subtypes and determines their relative clinical responsiveness.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com