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As a result of the higher risk profile, however, at least similar benefits might potentially be expected in trial-ineligible compared with trial-eligible patients.
They rather reflect some heterogeneity in treatment quality, which may be expected in any trial with a large number of participating centres.
Although some publications report test-rest correlation for the HAQ of more than 0.8 (31), there is no direct information about the correlation that is to be expected in our trial.
Quite detailed ophthalmology data were available but there were limited data from other measures of HRQoL as might be expected in a clinical trial, as trial participants may already be overburdened with clinical measurements required by the protocol.
As would be expected in a randomised trial, the groups were well matched.
Based on this and other recent studies, the authors warn that "some type of duplicity... can be expected in almost any clinical trial".
A verdict is expected in the trial of the fashion designer John Galliano, who was accused of launching an alcohol-fuelled racist tirade in a Paris bar.
It came just as a highly charged verdict is expected in the trial of a former head of military intelligence for the 1998 murder of Bishop Juan Gerardi Conedera, a diligent human rights advocate.
To clear all this up for us, and get a sense of what is expected in the trial, we hopped on the phone with Chet Kanojia to discuss the case.
24, 25 Adverse changes in seizures are expected in any trial of an epilepsy therapy and likely represent the natural fluctuation of seizures in patients who do not respond to the treatment.
As a result no short-term cognitive improvements are expected in such trials.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com