Some β-catenin target genes responded as predicted (Axin2, Lef1 ), others did not (c-Myc and Ccnd1 ) as is expected from cell type-specific β-catenin targets (Sansom et al., 2005 ; Sansom et al., 2007 )— andn2 and Lef1 data is also shown in Figure 4D to put them into the context of other expression changes.
As shown in Fig. 1 and supplementary material Fig. S2, at the end of one week pulse, cells throughout the polyp were labelled with EdU, as would be expected from hydra cell kinetics.
As might be expected from a critical cell cycle regulator, targeting CDC6 in cells lacking KRAS mutation also had significant growth inhibitory effects, although not as great as for the KRAS mutant cells.
Such data can be expected from human ES cell studies.
They harbour self-renewal, shown by in-vitro indefinite expansion and in-vivo serial transplantation experiments and differentiation capacity, as would be expected from a stem cell.
For DNA synthesis, the rate of [H]thymidine incorporation fell precipitously, as would be expected from the transition from cell replication to differentiation.
72 Also, interestingly, there was no evidence of an immune rejection reaction as might be expected from the use of cells from different individuals.
As might be expected from this result, TregHAR-Treg cells showed concordant regulation of previously described canonical Treg cell signature genes (Feuerer et al., 2010).
Increased carrier transportation performance and greater current can be expected from these multi-junction solar cells.
To determine if YC137 treatment acts by increasing autophagy, as might be expected from its inhibition of BCL2 [24], cells were treated with YC137 and/or ICI and examined for LC3 cleavage and p62/SQSTM1 expression by Western blotting.
