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In the Christopher-study PE could be excluded safely with a Wells-CDR cut-off value of ≤ 4 in 35.0% of the patients.
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Several management-studies in secondary care have demonstrated that PE can be excluded safely in patients with a low (<2) or unlikely (≤4) clinical probability according to the clinical decision rule (CDR) as developed by Wells et al. (Table 1), combined with a normal D-dimer test result (both quantitative and qualitative D-dimer tests) [ 5- 8].
In a recent study of 621 adult patients with acute cough or fever, 20.5% of whom had radiographically confirmed pneumonia, Steurer and co-workers concluded that pneumonia could safely be excluded in patients with CRP values below 10 mg/L and in patients without dyspnoea or daily fever with values between 11 and 50 mg/L [ 21].
Macrofauna was excluded with this mesh size.
Dead cells were excluded with 7AAD (Invitrogen).
Patients with APL were excluded.
Men with dementia were excluded.
Patients with malignancies were excluded.
Words with homophones were excluded.
HapMap markers with MAF<0.05 were excluded.
Samples with pH≤6.5 were excluded [39].
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