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Excision can be exceptionally difficult due to infection, inflammation and fibrosis of surrounding tissue, the need for venous bypass and the risk of recurrent infection.
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Synthesis of ethyl tert-buty ether (ETBE), a high-performance fuel additive, through reactive distillation (RD) is an attractive route, while its operation and control are exceptionally difficult due to its functional combination and complex dynamics.
Calculating sulfate reduction rates in Lake Kinneret is exceptionally difficult, due to mixing by high eddy diffusion in the lake, sulfate diffusion in and out of the sediment, and redox reactions involving sulfide oxidation or sulfur disproportionation that may mitigate any change in sulfate concentration.
Membrane proteins such as IP3R channels have proven to be exceptionally difficult targets for structural analysis due to their large size, their location in the membrane environment, and their dynamic nature.
Patti Smith: fascinating study of a woman thought to be exceptionally difficult to photograph.
Post-war reconciliation in Donetsk and Luhansk will thus be exceptionally difficult.
But given that the essence of cyber-warfare is ambiguity and uncertainty, gaining clarity and certainty will be exceptionally difficult.
Such an inquiry would be exceptionally difficult, since the relevant transaction would almost invariably have occurred outside our borders.
A prime example is crafting a fair and appropriate dress code, which can be exceptionally difficult.
BBC Scotland political editor Brian Taylor said that although Mr Murphy would be the front-runner, the timing would be "exceptionally difficult".
I suspect this will be exceptionally difficult in the current environment.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com