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The unpaired spacer regions between IRs may be eventually cleaved by DNases, as the tips of hairpin loops are sensitive to single-stranded nucleases [33] [37] resulting in long palindromes (Figure 6).
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The signal peptide is eventually cleaved by a serine protease, the signal peptidase, releasing the mature protein from the trans side of the membrane.
They were eventually cleared by the army.
Eventually, the fibrin is cleaved by plasmin into a soluble product.
In some cases, this leads to full viral amplification (AMDV NS1, HPV E1), with the striking example of AMDV NS1 protein that needs to be cleaved by caspases to translocate to the nucleus and eventually exert its functions.
Two out of these targets could be cleaved by engineered I-CreI derivatives, and we could improve the activity of weak novel meganucleases, to eventually match the activity of the parental I-CreI scaffold.
Dpp is cleaved off by Bmp1, while Dgp is cleaved by Mmp2 and Mmp20, multiple Mmps being found in dentine.
The disulfide linkage can be cleaved by reduced glutathione (GHS).
The amyloid precursor protein (APP) can be cleaved by alpha or beta secretase.
As a result, those proteins could be cleaved by indigenous protease easily.
By contrast, FXIII V34F AP could be cleaved by thrombin W60dA but not by Y60aA.
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