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Responses in skin and mHAQ-DI scores exceed those reported with other therapies, suggesting that HDIT is a promising new therapy for SSc that should be evaluated in prospective randomized studies.
Gated single-photon emission computed tomography imaging, which evaluates both myocardial perfusion and function, may represent a more effective means of risk stratification than solitary left ventricular ejection fraction determination and should be evaluated in prospective trials.
In these patients, treatment combinations of hyperthermia/chemotherapy and radiation/hyperthermia/chemotherapy have been shown to have promise, but these treatment combinations need to be evaluated in prospective trials.
When further validated in functional studies, specific kinase inhibitors that target AMPK pathway, LCK-mediated signalling and CYCLIN E activation could be evaluated in prospective clinical trials whereby patients who are in need of better therapeutic options could be selected and stratified for targeted therapeutics tailored to the molecular defect.
These have yet to be evaluated in prospective randomised trials.
Such recommendations have to be evaluated in prospective collaborative studies.
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Several of these approaches have been evaluated in prospective studies.
The clinical relevance and therapeutic consequence of any of these strategies, however, have so far not been evaluated in prospective studies, and their clinical value, therefore, remains uncertain.
Although all these relatively new biomarkers can be considered of additional value in relation to the prognosis of PE, they have not yet been evaluated in prospective studies, and their potential role as an independent predictor of adverse outcome in PE patients still needs to be determined.
Treat-and-extend is being evaluated in prospective clinical trials.
The role of rituximab is being evaluated in prospective trials.
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