Similarly, within the drug discovery pipeline ChEBI has been used as one of several systems within which chemicals can be classified or grouped in order for patterns to be evaluated in large-scale high-throughput data [26].
Although these agents may represent appropriate first-line therapies for men with OAB symptoms, the therapeutic potential of antimuscarinics alone or in combination with α1-receptor antagonists in this population should be evaluated in large-scale, well-designed clinical trials.
Again the clinical utility of these combinations needs to be evaluated in large-scale studies.
Such prototype will be evaluated in large-scale studies in humans in clinical and field settings in malaria-endemic countries.
This intervention is recommended with the provision that these outcomes be evaluated in large-scale effectiveness settings.
Given the constancy of exposure, it is critical that the impact of passive smoke on CRS exacerbation, outcomes, and pathophysiology be evaluated in large-scale clinical studies.
The questions that remain to be evaluated in large-scale, randomized controlled trials of probiotics use in NP include the optimal type of probiotic preparation, administration route, dose intensity, timing and duration of administration, safety, patient eligibility, and contraindications.
The safety and efficacy of several of these promising thrombolytic drugs have been evaluated in large-scale trials, which are discussed in the present review.
Although the efficacy of angiotensin II receptor blockers (ARBs) in hypertension and left ventricular hypertrophy regression has been established, the effect of angiotensin II receptor blockade on intrinsic parameters of diastolic function has not been evaluated in large-scale studies.
Various types of assays have been tested in a variety of malignancies, but none so far has been evaluated in large-scale randomised clinical trials.
