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This approach can now be evaluated in human clinical trials in AIDS lymphoma patients.
The effectiveness of cell therapy could also be evaluated in human neuromuscular disorders caused by mutations in other myotubularin family genes.
Because it has been administrated for many years to treat hypertension on a daily basis, without major side-effects, our results suggest that it could be evaluated in human as a potential treatment for prion-based diseases.
Despite these significant advantages, there exists a significant hurdle before patient-derived iPS cells could be evaluated in human patients.
We therefore propose that certain age-sensitive variables identified in our study be considered for inclusion within a panel of "validation measures", that once developed, could serve as a standard set of traits to be evaluated in human studies of anti-aging interventions.
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To potentially further broaden protection, MVDB is developing a second generation vaccine which will combine a third, more divergent AMA1 allele with AMA1-C1 and which will be evaluated in humans in the near future.
The function of the β-cell can be evaluated in humans in different ways.
Therefore, for any iPSC-derived cell-replacement treatment to be evaluated in humans, technological advances have to be made to reduce the carcinogenic risks of iPSCs significantly.
The effects of this remodelling need to be evaluated in humans to allow a definitive prediction of the translational potential of this combinatorial therapy.
Vesico-urethral function may be evaluated in humans and dogs by conventional urodynamic testing (cystometry and urethral pressure profilometry) or by electromyography.
Some have also been evaluated in human beings [ 13- 15].
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