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In addition, the expectation of the participants and their confidence with the treatment will be evaluated before randomisation and after the first treatment session, respectively.
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The general and specific disability of the patient, kinesiophobia, pain intensity and global perceived effect will be evaluated by a blinded assessor before randomisation and at six weeks and six months after randomisation.
All other patients will primarily be evaluated in an ITT analysis according to allocation by randomisation.
Before randomisation, EGFR expression was evaluated locally from tumour specimens using a standardised immunohistochemistry assay (EGFR pharmDx Dako, Glostrup, Denmark).
Participants were evaluated by independent assessors blind to study arm allocation before randomisation (0 months), three months after randomisation (at the end of the treatment period for patients who received the intervention), and again at six months after randomisation.
Studies were evaluated on a five-point scale based on randomisation, double-blinding and follow-up.
In open randomised trials, preferences should be ascertained before randomisation.
To evaluate whether lack of blinding is associated with bias, expectations and preferences of patients will be measured before randomisation and after treatment allocation.
Baseline HRQoL questionnaires had to be completed before randomisation.
The baseline questionnaires and demographics will be registered before randomisation.
Baseline eligibility data will be required before randomisation.
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