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The exact effect size can only be estimated in randomized trials, which may be challenging and of moderate value unless each individual component of the bundle is tested in a separate trial [ 1, 25].
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The detrimental effect of delaying surgical revascularization has been estimated in randomized trials and observational studies.
17 The cost-effectiveness of ramipril versus placebo has been estimated in two large, randomized, prospective studies, ie, HOPE and AIRE.
These findings support the 76% overall risk reduction in congestive heart failure that was estimated in a meta-analysis of several large randomized controlled studies of patients treated with doxorubicin or epirubicin where dexrazoxane was given from the first dose of anthracycline.
As a comparison, AUC values were also estimated in randomized versions of the SanchezC and Stransky datasets.
Local control will be estimated as the parameter for randomized treatment in a Cox proportional hazard model with age as additional explanatory variable.
In theory, overdiagnosis can be estimated by comparison of incidence in a randomized trial of screening, but this would require that the control group was never screened and that both intervention and control groups were followed up to expiry or for more than at least two decades.
For Olea europaea and Schefflera abyssinica, fecundity was estimated using randomized branch sampling.
Here, Leish-Tec® efficacy was estimated through a randomized field trial (RFT), in a highly VL endemic area.
Drug efficacy was estimated from a randomized, open-label, controlled, multicenter, Phase 4 study (trial 1002) which compared linezolid with vancomycin therapy in patients with MRSA-confirmed cSSTI.
In this approach, sample size for clustered randomized trials was estimated taking into account the role of the planned trial on a future meta-analysis [ 48].
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