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The agreement was that for eLife, causality of methylation and RNA expression changes would have to be established, using either chemical treatment or appropriate mutants.
[Editors' note: the author responses to the previous round of peer review follow.] The agreement was that for eLife, causality of methylation and RNA expression changes would have to be established, using either chemical treatment or appropriate mutants.
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Means and standard errors of the mean are presented, and significance was established using either Student's t-test or analysis of variance (ANOVA).
The significance of plasticity changes (LTP and CCh-LTD) was established using either paired or unpaired two-tailed t-tests as appropriate.
Two sets of population cages were established using either 50 RR 5-generation-backcrossed virgin females or males crossed to 50 SS males or 50 SS virgin females (RR × SS and SS × RR), respectively.
For patients with at least 4 days of fever, the diagnosis of Kawasaki disease was established using either four or more principal clinical criteria for Kawasaki disease or a coronary artery z-score of 2.5 or more for the proximal right coronary artery or the left anterior descending coronary artery, as measured by two-dimensional echocardiography (Newburger et al, 2004).
Equations to predict 17β-estradiol, estriol, estrone or equol Kd or Koc values at the regional level were established using either soil properties (Partial Least Squares (PLS) regression) or one single estrogen (ordinary least squares regression).
Venous access was established using either the cephalic or the sub-clavian vein, and the pocket for the device was made.
The statistical significance of differences between the groups was established using either an ANOVA test for comparisons of means or a χ2 test for comparison of categorical data.
Rings can be established using a single-well or multichannel pipette.
A reliable knowledge base can be established using inference power.
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