Furthermore, many of these studies provide only a snapshot of the epigenetic profile after the disease process has been established, rather than describing a temporal relationship between an epigenetic alteration and subsequent disease development.
However, because no reliable correlation between intravascular volume and absolute CVP measurement has been established, rather than apply an absolute target for CVP, dynamic changes of CVP to fluid challenge would likely provide a more reliable guide to fluid requirements [ 24, 36].
The first criterion Nagel mentions is that the premises of a reduction the bridge laws and the reducing theory—should be well established rather than arbitrarily chosen (1961: 358).
This observation is consistent with the late or minimal involvement of brainstem dopaminergic projection neurones in many DLB cases and suggests that the optimal time point for dopamine transporter imaging may be in established rather than prodromal disease.
Thus, the indispensible role of Nde1 in generating layer II/III neurons appears to be at the time when the fate of these neurons is initially established rather than when they are generated through terminal mitosis.
"It's easier to build a habit off of old neural pathways that are already established rather than forging new ones," Serin says.
While many studies have previously looked at the association between dental fear and control, the major focus of most of this research has been on the use of control as an intervention to modify fear once it is already established rather than on control, or lack of, as an antecedent of fear.
The fringe seemed to aspire to be a microcosm of West End productions rather than a place to fuel and challenge mainstream theatre – there seemed to be established formulae rather than experiment and all fringe spaces looked the same (black and small).
