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There is no gold standard for animal testing but proof of principle can be established in small rodents.
In the past similar techniques have been applied to large scale studies but it sperformance is yet to be established in small scale clinical studies thus the contribution of this paper is in justifying the validity of these techniques for small samples too.
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Another factor possibly related to the pattern observed is population density: in small frogs, a viable population could be established in smaller ranges than in large frogs [ 51], potentially driving the correlated evolution of microendemism.
Carménère has also been established in small amounts in New Zealand.
Although the antitussive effects of codeine in patients with chronic bronchitis were established in small patient populations, and there have been no double-blind, placebo-controlled studies of codeine in cough due to acute bronchitis, it is reasonable to presume that codeine is effective under these circumstances [ 39].
In recent weeks four more corralas have been established in smaller towns in Andalusia and another in the city of Málaga, where the unemployment statistics and the number of empty houses are even higher than in Seville.
No relation could be established in this small set of patients (data not shown).
The comparison of patient medication records against self reported medication history on the DAMS could only be established in a small number of patients (n = 16), which was a limitation to this part of the analysis.
Although a correlation between clinical outcome and immunological endpoints could not be established in this small cohort of patients, monitoring of ζ-chain expression, the frequency of PSA specific T cells and the cytokine profile may be able to define patients who are capable of mounting a cellular response against the tumour.
The plants can be established in three sizes (small, medium and large).
The plants producing biofuels could be established in three sizes: small, medium and large.
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