Sentence examples for be established by further from inspiring English sources

These data suggest a specific role for the hypomethylated ETS motif-mediated PARP1 overexpression in EC progression, but a clear molecular model regarding how the abnormal methylation of the ETS motif affects the transcription of PARP1 needs to be established by further experimental evidence.

Whether simply inhibiting MDM2 synthesis is most effectively achieved via targeting of splicing as described in the present report or through direct translational inhibition as previously found [ 20] remains to be established by further optimization and direct comparison although the data so far indicate comparable potency.

The structure of 1 was established by the further 2D NMR data analysis.

Even though the significance of GLI-1 regulation by RANKL has been established by silencing studies, further studies are required to complete our knowledge on RANKL-induced activation of GLI-1.

The letter as a verse form, beginning with striking examples by Catullus, was established by Horace, whose Epistles carry still further the humane refinement of his gentler satires.

Further confirmation was established by observing the lack of lytic action of YD1 in whole cells of E. coli and >88% intact surviving spheroplasts [Fig. 5a (iv), b].

The range of validity of these criteria and the areas for further improvement were established by comparison with the numerical results.

It was established by Miskito settlers from a community further north (Sandy Bay) in 1860 (Jamieson 1995).

This equation was established by Piringer in the 1990s, and further validated and refined within European Union Project SMT4-CT98-7513 (Begley et al. 2005; Mercea & Piringer  2008).

In mid-2009, Renewaslestablishedtabyished by the South Australian Government to encourage further investment in renewable energy to the state.

Typically, a gigaohm seal was formed by a small negative pressure, and whole-cell recording was established by rupture of the cell membrane with further negative pressure or a buzz signal, or a combination of both.