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However, the long-term prognostic value of these biomarkers, especially in relation to radiographic progression and functional disability, remains to be established, as does their potential to guide future cost-effective therapies, of particular importance in resource-limited settings.
However, the relative abundance of these factors and whether they are able to compete with α-importins for PABP-binding remains to be established as does the binding sites for many other PABP protein partners.
To what extent these children and their responses to intervention are similar to those selected using a stricter criteria remains to be established, as does whether different subtypes of dyscalculia might respond differently.
In patients selected at high risk for postextubation stridor (for example, traumatic intubation, low cuff-leak value or previous extubation failure) steroids should be used but the optimal steroid to use before extubation without delay remains to be established, as does steroid type, dosing regimen, administration timing and duration.
However, the precise role these hormones play in the glucose lowering and other metabolic advantages imposed by bariatric surgery remains to be established, as does RYGB-induced alterations in the recirculation of bile acids (increasingly being recognized as metabolic regulators, e.g., via activation of TGR5 on GLP-1 secreting GLP-1 secreting
Whether broad-spectrum anti-SMEZ responses are a result of a few cross-reacting antibodies that were raised against a single SMEZ variant has yet to be established, as does whether it results from infection by multiple GAS strains carrying different smez alleles over a certain period.
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For example, standard neoadjuvant, or conversion therapy regimen before hepatic resection, needs to be established, as do adjuvant therapy after hepatic resection and optimal liver-specific chemotherapy.
Thus, the severity and pattern of symptoms of ASD at a young age need to be established, as do the inter-rater reliability and stability of the early diagnosis.
The mode of 12(S -HETE-induced activation of NF- κB in LECS -HETE-induced eS -HETE-inducedwe did not observe activatione in E-selectin mRNA levels upof 12(S)-HETE treatment (data not shown).
Of note is that the identities for 1,070 (55%) of these OvAEs could not yet be established, as they did not share sequence homology (BLASTx/tBLASTx) with any other predicted or known molecules in public databases, including dbEST which contains 2,678 ESTs from the related liver fluke, C. sinensis [ 9].
However, before tests like the STS or handgrip strength test are routinely used in trials, their responsiveness to change and minimal important difference need to be established, as has been done for the 6MWD [ 20].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com